CBD for Everyday Wellness

What is CBD?

CBD (cannabidiol) is a non-psychoactive component from the cannabis plant. CBD is one of many active components in the plant. Scientific and clinical research has proven its medicinal benefits and therapeutic value. CBD can be found throughout the seeds, stalk and flowers of cannabis plants, including hemp and marijuana.
According to a study conducted in 2010, Hemp oil (also known as CBD oil) has been used in human diets for “hundreds of years.” [1] However, throughout the centuries, the status of cannabis has become controversial and the legality widely debated in the U.S.
Today, many states have already legalized the cultivation of hemp for commercial, research or pilot programs, and the benefits of CBD are beginning to unfold. Although the use of CBD oil is new amongst many, it is quickly becoming a popular approach and gaining way into main stream culture.

Effects of CBD inside the body 
Inside the human body, cannabinoid receptors are involved in a series of processes; including the regulation of mood, pain sensation, appetite and memory. Because the human body naturally produces endocannabinoids, these receptors are activated when consuming CBD from hemp or marijuana. Grouped in two main categories, CB1 and CB2 are found mostly in the central nervous system. A small number can also be found in the liver, kidneys and lungs. CB1 receptors are involved in playing a role in the maintenance of the body’s internal equilibrium, also known as homeostasis. [3] CB2 receptors are part of the immune system and found in all cellular blood components.  [2] CBD activates other receptors, such as the adenosine, serotonin, and vanilloid receptors.

When adenosine receptors are activated by CBD, the anti-anxiety and anti-inflammatory effects of CBD take effect. Adenosine receptors are also involved in the release of two neurotransmitters that play major roles inside the body. These two neurotransmitters are dopamine, which is involved in cognition, motor control, motivation and reward mechanisms, and the other is  glutamate, being involved in memory, learning and cognition[4]

CBD is all natural
Cannabis is an all-natural herb; an alternative medicine that provides a wide range of benefits. Organic drugs can produce certain effects without being chemically altered. They are often plant based substances that grow naturally in certain environments, such as cannabis. Synthetic drugs on the other hand, are man-made chemicals, and most come with a long list of side-effects. One should avoid regularly consuming synthetic drugs that can later be more harmful and dangerous. CBD is a natural alternative that may treat ailments without the side effects that synthetic drugs can cause. For this reason alone, turning to an alternative, all-natural option can be truly beneficial in your everyday life.

CBD is non-psychoactive
CBD is non-psychoactive because it does not act on the same pathways as THC. [5] CBD is typically the second most prevalent cannabinoid present in cannabis plants, after THC. However, modern research has allowed for strains of marijuana to be modified to contain very little to no THC. So, you can now benefit from the healing components of cannabis without getting high! It is also good to know that although THC and CBD are two distinctive compounds, they work together in enhancing the positive qualities of the other. This is called the “entourage effect.” For example, for many, pure THC can cause anxiety. However, when THC is mixed with CBD, many users experience relaxation. CBD can counteract the THC “high” in cannabis. [6] Different cannabis strains can differ greatly in ratios of cannabinoids, and different ratios can create different experiences.

CBD reduces nervous disorders
There have been studies in which CBD medical treatment has had reduction in the anxiolytic features amongst many groups. According to several studies, provided by projectcbd.org, researchers concluded that “[CBD] significantly reduced anxiety, cognitive impairment, and discomfort in their speech performance,” whereas the placebo group experienced “higher anxiety, cognitive impairment, [and] discomfort.” [7] The ongoing, emerging human clinical data shows the positive results of using hemp-derived CBD-rich extracts for modulating fear, anxiety and a healthy stress response. [8] [9]

There have also been experimental studies that suggest that CBD may decrease anxiety and increase mental sedation in healthy individuals. Clinical trials suggest the high-dose CBD may be useful for the treatment of social anxiety disorder, and possibly, insomnia; a study published in the journal of medicinal chemistry and related drug sciences; Pharmaceuticals[10]  [11]

CBD reduces blood sugar levels
It has been found that cannabis helps people regulate their weight through regulating blood sugar levels. The American Journal of Epidemiology conducted a study that found a fascinating connection between cannabis use and body weight. This study showed that rates of obesity were lower by about a third in people who smoke cannabis at least three times a week, compared with those who didn’t use cannabis at all. [12]

In another large national survey of the American population data was analyzed by researchers. This study included about 52,000 participants, and it was found that 22% of those who did not smoke cannabis were obese, compared to 14% of the regular cannabis smokers.

In the scientific journal Molecular and Cellular Biochemistry, researchers studied the effects of CBD administration on immature fat cells to learn potential benefits on the treatment and prevention of obesity. While it was found that fat cell generation was decreased, CBD also stimulates genes and proteins to speed the breakdown and oxidation of fat. The increase number and activity of mitochondria increases the body’s ability to burn calories. Turns out that the active component of cannabis may help kick start your metabolism into overdrive! [13]

CBD as a Supplement
In an age where many of us fail to gain the appropriate levels of important vitamins and minerals in our diets, it helps to gain them from an all-natural, and harmless source. Hemp CBD oil contains an extensive list of naturally occurring vitamins, including, vtamins A, C, and E., and as well as B complex vitamins. [15]  Hemp seed and hemp oil is considered an excellent source of essential omega-3 and omega-6, omega 9 fatty acids which can benefit human health in many ways. Being a healthy source of protein, nine out of the 20 amino acids that hemp oil includes are essential to us in our everyday diet. [14]  [15] Hemp CBD oil can help the human condition and support preventive medicine in our bodies and minds. Ingestion of hemp CBD oil each day can make us healthier.

CBD inhibits cancer cell growth
In August 2015, the National Cancer Institute (NCI) released a report on their website which stated, “Marijuana kills cancer”.  [16] Many studies have shown that THC and CBD cannabinoids have the ability to kill cancer cells. Many users currently use CBD to help in cancer treatment.

Two structures in most cells that sustains life are the mitochondria, and the endoplasmic reticulum. It was found that when THC hits the receptor, the cell generates lipid molecules that disrupts the mitochondria; this closes off energy for the cancerous cell. This kills the cancer cell due to the very small shift in the mitochondria. The primary job of CBD in the cancer cell is to disrupt the endoplasmic reticulum. This occurs when calcium is pushed into the cytosol, wrecking the calcium metabolism and resulting in cell death. Caspase Cascade is another pathway for CBD to effect cancer cell death. In this pathway, proteins and peptides in the cell breaks down. When this happens, the cancerous cell cannot survive, leaving the normal cell unaffected. [17]

CBD reduces chronic pain and inflammation
Research has shown that CBD oil does help with pain management. Although there are a few randomized clinical trials measuring the effects of cannabidiol oil intake on pain management, preliminary studies suggest the use of CBD’s in chronic pain management to be useful allowing an increase in quality of life and the ability to rest without pain.  CBD has shown to alleviate chronic pain. It helps in autoimmune conditions. CBD, THC and the by-product of its metabolism have anti-inflammatory and pain-killing (analgesic) properties. A controlled test conducted by the British Royal National Hospital in January 2006 was the first controlled trial to investigate whether cannabis extracts could effectively treat rheumatoid arthritis. [18] Over a five-week period, an improvement in pain when moving and resting was reported. While experiencing less inflammation and less intense pain, patients also slept better. The study found that those suffering from arthritis and rheumatoid arthritis may be able to slow the progress of the disease using CBD. Though there is still a need for more research, you can use cannabidiol-rich cannabis extracts as a natural treatment for chronic pain and inflammation today! Used by many who experience chronic pain, CBD may reduce pain, inflammation, and overall discomfort related to a variety of health conditions.

So why wouldn’t we look into something, now more attainable than ever, that has the potential to aid us? To aid our minds and bodies. An alternative way to heal ourselves without desensitizing from our daily life.

References:
[1]  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868018/
[2].  http://www.ncbi.nlm.nih.gov/pubmed/10469884
[3] http://norml.org/library/item/introduction-to-the-endocannabinoid-system
[4] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575333/
[5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797438/
[7] https://www.ncbi.nlm.nih.gov/pubmed/21307846
[8] https://www.scribd.com/document/341507129/Lee-Et-Al-2017-British-Journal-of-Pharmacology#from_embed
[9] file:///C:/Users/kmbbe/Downloads/fphar-07-00454.pdf
[10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763649/
[11] http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462012000500008&lng=en&nrm=iso&tlng=en
[12] https://academic.oup.com/aje/article/174/8/929/155851/Obesity-and-Cannabis-Use-Results-From-2
[13] https://www.ncbi.nlm.nih.gov/pubmed/27067870
[14] http://herb.co/2015/03/23/enhancing-your-endocannabinoid-system-with-omega-3-fatty-acids/
[15] https://echoconnection.org/full-spectrum-hemp-oil-important/
[16] https://www.cancer.gov/about-cancer/treatment/cam/patient/cannabis-pdq/#link/_13
[17] https://patients4medicalmarijuana.wordpress.com/how-cannabinoids-kill-cancer-dennis-hill/
[18] https://academic.oup.com/rheumatology/article/45/1/50/1788693/Preliminary-assessment-of-the-efficacy

While we love talking about the science of medical cannabis here at KB Pure Essentials, we are not doctors and do not give medical advice. The shared information and discussion is for educational and conversational purposes only. 

The statements have not been evaluated by the FDA. This information is not intended to treat, cure, prevent, or diagnose any disease.

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